1: Aisen PS, Andrieu S, Sampaio C, Carrillo M, Khachaturian ZS, Dubois B, Feldman
HH, Petersen RC, Siemers E, Doody RS, Hendrix SB, Grundman M, Schneider LS,
Schindler RJ, Salmon E, Potter WZ, Thomas RG, Salmon D, Donohue M, Bednar MM,
Touchon J, Vellas B. Report of the task force on designing clinical trials in
early (predementia) AD. Neurology. 2010 Dec 22. [Epub ahead of print] PubMed
PMID: 21178097.


2: Black RS, Sperling RA, Safirstein B, Motter RN, Pallay A, Nichols A, Grundman 
M. A single ascending dose study of bapineuzumab in patients with Alzheimer
disease. Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):198-203. PubMed PMID:
20505438.


3: Cedarbaum JM, Crans G, Grundman M. Seeing with new eyes: finding a path to
early intervention trials in Alzheimer's disease. J Nutr Health Aging.
2010;14(4):306-9. PubMed PMID: 20306002.


4: Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA,
Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P,
Albert MS, Breitner JC, Buckholtz N, Carrillo M, Ferris S, Greenberg BD, Grundman
M, Khachaturian AS, Kuller LH, Lopez OL, Maruff P, Mohs RC, Morrison-Bogorad M,
Phelps C, Reiman E, Sabbagh M, Sano M, Schneider LS, Siemers E, Tariot P, Touchon
J, Vellas B, Bain LJ. Developing a national strategy to prevent dementia: Leon
Thal Symposium 2009. Alzheimers Dement. 2010 Mar;6(2):89-97. PubMed PMID:
20298968.


5: Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, Mathis CA,
Blennow K, Barakos J, Okello AA, Rodriguez Martinez de Liano S, Liu E, Koller M, 
Gregg KM, Schenk D, Black R, Grundman M. 11C-PiB PET assessment of change in
fibrillar amyloid-beta load in patients with Alzheimer's disease treated with
bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. 
Lancet Neurol. 2010 Apr;9(4):363-72. Epub 2010 Feb 26. PubMed PMID: 20189881.


6: Salloway S, Sperling R, Gilman S, Fox NC, Blennow K, Raskind M, Sabbagh M,
Honig LS, Doody R, van Dyck CH, Mulnard R, Barakos J, Gregg KM, Liu E, Lieberburg
I, Schenk D, Black R, Grundman M; Bapineuzumab 201 Clinical Trial Investigators. 
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate
Alzheimer disease. Neurology. 2009 Dec 15;73(24):2061-70. Epub 2009 Nov 18.
PubMed PMID: 19923550; PubMed Central PMCID: PMC2790221.


7: Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL; Alzheimer's
Disease Cooperative Study Group. Donepezil delays progression to AD in MCI
subjects with depressive symptoms. Neurology. 2009 Jun 16;72(24):2115-21. PubMed 
PMID: 19528519; PubMed Central PMCID: PMC2697965.


8: Ryan JM, Grundman M. Anti-amyloid-beta immunotherapy in Alzheimer's disease:
ACC-001 clinical trials are ongoing. J Alzheimers Dis. 2009;17(2):243. PubMed
PMID: 19502708.


9: Price JL, McKeel DW Jr, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA,
Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery
WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC.
Neuropathology of nondemented aging: presumptive evidence for preclinical
Alzheimer disease. Neurobiol Aging. 2009 Jul;30(7):1026-36. Epub 2009 Apr 18.
PubMed PMID: 19376612; PubMed Central PMCID: PMC2737680.


10: Vellas B, Black R, Thal LJ, Fox NC, Daniels M, McLennan G, Tompkins C,
Leibman C, Pomfret M, Grundman M; AN1792 (QS-21)-251 Study Team. Long-term
follow-up of patients immunized with AN1792: reduced functional decline in
antibody responders. Curr Alzheimer Res. 2009 Apr;6(2):144-51. PubMed PMID:
19355849; PubMed Central PMCID: PMC2825665.


11: Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA,
Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS,
Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirier
J, Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H,
Grundman M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs
RC, Carrillo M, Corey-Bloom JP, Foster NL, Jacobsen S, Lee V, Potter WZ, Sabbagh 
MN, Salmon D, Trojanowski JQ, Wexler N, Bain LJ. A roadmap for the prevention of 
dementia II: Leon Thal Symposium 2008. Alzheimers Dement. 2009 Mar;5(2):85-92.
PubMed PMID: 19328434.


12: Hauber AB, Johnson FR, Fillit H, Mohamed AF, Leibman C, Arrighi HM, Grundman 
M, Townsend RJ. Older Americans' risk-benefit preferences for modifying the
course of Alzheimer disease. Alzheimer Dis Assoc Disord. 2009
Jan-Mar;23(1):23-32. PubMed PMID: 18725862.


13: Grundman M, Gilman S, Black RS, Fox NC, Koller M. An alternative method for
estimating efficacy of the AN1792 vaccine for Alzheimer disease. Neurology. 2008 
Aug 26;71(9):697; author reply 697-8. PubMed PMID: 18725601.


14: Grundman M. A quarter century of advancing treatment for Alzheimer's disease 
with Leon J. Thal. Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S51-5. Epub 2007 Dec 
21. PubMed PMID: 18632001.


15: Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans 
B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS,
Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski
MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye 
J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, 
Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J,
Khachaturian AS, Bain LJ. A roadmap for the prevention of dementia: the inaugural
Leon Thal Symposium. Alzheimers Dement. 2008 May;4(3):156-63. PubMed PMID:
18631960; PubMed Central PMCID: PMC2544623.


16: Pride M, Seubert P, Grundman M, Hagen M, Eldridge J, Black RS. Progress in
the active immunotherapeutic approach to Alzheimer's disease: clinical
investigations into AN1792-associated meningoencephalitis. Neurodegener Dis.
2008;5(3-4):194-6. Epub 2008 Mar 6. Review. PubMed PMID: 18322388.


17: Ridha BH, Anderson VM, Barnes J, Boyes RG, Price SL, Rossor MN, Whitwell JL, 
Jenkins L, Black RS, Grundman M, Fox NC. Volumetric MRI and cognitive measures in
Alzheimer disease : comparison of markers of progression. J Neurol. 2008
Apr;255(4):567-74. Epub 2008 Feb 18. PubMed PMID: 18274807.


18: Harrison J, Minassian SL, Jenkins L, Black RS, Koller M, Grundman M. A
neuropsychological test battery for use in Alzheimer disease clinical trials.
Arch Neurol. 2007 Sep;64(9):1323-9. PubMed PMID: 17846273.


19: DeCarli C, Frisoni GB, Clark CM, Harvey D, Grundman M, Petersen RC, Thal LJ, 
Jin S, Jack CR Jr, Scheltens P; Alzheimer's Disease Cooperative Study Group.
Qualitative estimates of medial temporal atrophy as a predictor of progression
from mild cognitive impairment to dementia. Arch Neurol. 2007 Jan;64(1):108-15.
Erratum in: Arch Neurol. 2007 Mar;64(3):459. PubMed PMID: 17210817.


20: Schenk DB, Seubert P, Grundman M, Black R. A beta immunotherapy: Lessons
learned for potential treatment of Alzheimer's disease. Neurodegener Dis.
2005;2(5):255-60. Review. PubMed PMID: 16909006.


21: Grundman M, Petersen RC, Bennett DA, Feldman HH, Salloway S, Visser PJ, Thal 
LJ, Schenk D, Khachaturian Z, Thies W; Alzheimer's Association Research
Roundtable. Alzheimer's Association Research Roundtable Meeting on Mild Cognitive
Impairment: what have we learned? Alzheimers Dement. 2006 Jul;2(3):220-33. PubMed
PMID: 19595891.


22: Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, 
Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ; Alzheimer's
Disease Cooperative Study Group. Vitamin E and donepezil for the treatment of
mild cognitive impairment. N Engl J Med. 2005 Jun 9;352(23):2379-88. Epub 2005
Apr 13. PubMed PMID: 15829527.


23: Grundman M. Weight loss in the elderly may be a sign of impending dementia.
Arch Neurol. 2005 Jan;62(1):20-2. PubMed PMID: 15642845.


24: Grundman M, Petersen RC, Ferris SH, Thomas RG, Aisen PS, Bennett DA, Foster
NL, Jack CR Jr, Galasko DR, Doody R, Kaye J, Sano M, Mohs R, Gauthier S, Kim HT, 
Jin S, Schultz AN, Schafer K, Mulnard R, van Dyck CH, Mintzer J, Zamrini EY,
Cahn-Weiner D, Thal LJ; Alzheimer's Disease Cooperative Study. Mild cognitive
impairment can be distinguished from Alzheimer disease and normal aging for
clinical trials. Arch Neurol. 2004 Jan;61(1):59-66. PubMed PMID: 14732621.


25: Thal LJ, Grundman M, Berg J, Ernstrom K, Margolin R, Pfeiffer E, Weiner MF,
Zamrini E, Thomas RG. Idebenone treatment fails to slow cognitive decline in
Alzheimer's disease. Neurology. 2003 Dec 9;61(11):1498-502. PubMed PMID:
14663031.


26: Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, Thomas R,
Thal LJ; Alzheimer's Disease Cooperative Study. A multicenter, placebo-controlled
trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep. 2003 Nov 
1;26(7):893-901. PubMed PMID: 14655926.


27: Ji M, Xiong C, Grundman M. Hypothesis testing of a change point during
cognitive decline among Alzheimer's disease patients. J Alzheimers Dis. 2003
Oct;5(5):375-82. PubMed PMID: 14646028.


28: Pasquier F, Fukui T, Sarazin M, Pijnenburg Y, Diehl J, Grundman M, Miller BL.
Laboratory investigations and treatment in frontotemporal dementia. Ann Neurol.
2003;54 Suppl 5:S32-5. Review. PubMed PMID: 12833367.


29: Aisen PS, Schafer KA, Grundman M, Pfeiffer E, Sano M, Davis KL, Farlow MR,
Jin S, Thomas RG, Thal LJ; Alzheimer's Disease Cooperative Study. Effects of
rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized
controlled trial. JAMA. 2003 Jun 4;289(21):2819-26. PubMed PMID: 12783912.


30: Grundman M, Capparelli E, Kim HT, Morris JC, Farlow M, Rubin EH, Heidebrink
J, Hake A, Ho G, Schultz AN, Schafer K, Houston W, Thomas R, Thal LJ; Alzheimer's
Disease Cooperative Study. A multicenter, randomized, placebo controlled,
multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild
Alzheimer's disease patients. Life Sci. 2003 Jun 20;73(5):539-53. PubMed PMID:
12770610.


31: Aisen PS, Schafer K, Grundman M, Thomas R, Thal LJ. NSAIDs and hypertension. 
Arch Intern Med. 2003 May 12;163(9):1115; author reply 1115-6. PubMed PMID:
12742818.


32: Thal LJ, Thomas RG, Mulnard R, Sano M, Grundman M, Schneider L. Estrogen
levels do not correlate with improvement in cognition. Arch Neurol. 2003
Feb;60(2):209-12. PubMed PMID: 12580705.


33: Grundman M, Sencakova D, Jack CR Jr, Petersen RC, Kim HT, Schultz A, Weiner
MF, DeCarli C, DeKosky ST, van Dyck C, Thomas RG, Thal LJ; Alzheimer's Disease
Cooperative Study. Brain MRI hippocampal volume and prediction of clinical status
in a mild cognitive impairment trial. J Mol Neurosci. 2002 Aug-Oct;19(1-2):23-7. 
PubMed PMID: 12212787.


34: Grundman M, Grundman M, Delaney P. Antioxidant strategies for Alzheimer's
disease. Proc Nutr Soc. 2002 May;61(2):191-202. Review. PubMed PMID: 12133201.


35: Teri L, Logsdon RG, Peskind E, Raskind M, Weiner MF, Tractenberg RE, Foster
NL, Schneider LS, Sano M, Whitehouse P, Tariot P, Mellow AM, Auchus AP, Grundman 
M, Thomas RG, Schafer K, Thal LJ; Alzheimer's Disease Cooperative Study.
Treatment of agitation in AD: a randomized, placebo-controlled clinical trial.
Neurology. 2000 Nov 14;55(9):1271-8. Erratum in: Neurology 2001 Feb 13;56(3):426.
PubMed PMID: 11087767.


36: Tractenberg RE, Patterson M, Weiner MF, Teri L, Grundman M, Thomas RG, Thal
LJ. Prevalence of symptoms on the CERAD behavior rating scale for dementia in
normal elderly subjects and Alzheimer's disease patients. J Neuropsychiatry Clin 
Neurosci. 2000 Fall;12(4):472-9. Erratum in: J Neuropsychiatry Clin Neurosci 2001
Winter;13(1):95. PubMed PMID: 11083164.


37: Grundman M, Thal LJ. Treatment of Alzheimer's disease: rationale and
strategies. Neurol Clin. 2000 Nov;18(4):807-28. Review. PubMed PMID: 11072262.


38: Mulnard RA, Cotman CW, Kawas C, van Dyck CH, Sano M, Doody R, Koss E,
Pfeiffer E, Jin S, Gamst A, Grundman M, Thomas R, Thal LJ. Estrogen replacement
therapy for treatment of mild to moderate Alzheimer disease: a randomized
controlled trial. Alzheimer's Disease Cooperative Study. JAMA. 2000 Feb
23;283(8):1007-15. Erratum in: JAMA 2000 Nov 22-29;284(20):2597. PubMed PMID:
10697060.


39: Aisen PS, Davis KL, Berg JD, Schafer K, Campbell K, Thomas RG, Weiner MF,
Farlow MR, Sano M, Grundman M, Thal LJ. A randomized controlled trial of
prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
Neurology. 2000 Feb 8;54(3):588-93. PubMed PMID: 10680787.


40: Grundman M. Vitamin E and Alzheimer disease: the basis for additional
clinical trials. Am J Clin Nutr. 2000 Feb;71(2):630S-636S. Review. PubMed PMID:
10681271.


41: Logsdon RG, Teri L, Weiner MF, Gibbons LE, Raskind M, Peskind E, Grundman M, 
Koss E, Thomas RG, Thal LJ. Assessment of agitation in Alzheimer's disease: the
agitated behavior in dementia scale. Alzheimer's Disease Cooperative Study. J Am 
Geriatr Soc. 1999 Nov;47(11):1354-8. PubMed PMID: 10573447.


42: Hohl U, Grundman M, Salmon DP, Thomas RG, Thal LJ. Mini-Mental State
Examination and Mattis Dementia Rating Scale performance differs in Hispanic and 
non-Hispanic Alzheimer's disease patients. J Int Neuropsychol Soc. 1999
May;5(4):301-7. PubMed PMID: 10349293.


43: Knopman DS, Berg JD, Thomas R, Grundman M, Thal LJ, Sano M. Nursing home
placement is related to dementia progression: experience from a clinical trial.
Alzheimer's Disease Cooperative Study. Neurology. 1999 Mar 10;52(4):714-8. PubMed
PMID: 10078715.


44: Grundman M, Corey-Bloom J, Thal LJ. Perspectives in clinical Alzheimer's
disease research and the development of antidementia drugs. J Neural Transm
Suppl. 1998;53:255-75. Review. PubMed PMID: 9700663.


45: Olichney JM, Sabbagh MN, Hofstetter CR, Galasko D, Grundman M, Katzman R,
Thal LJ. The impact of apolipoprotein E4 on cause of death in Alzheimer's
disease. Neurology. 1997 Jul;49(1):76-81. PubMed PMID: 9222173.


46: Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, 
Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ. A controlled trial of
selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The
Alzheimer's Disease Cooperative Study. N Engl J Med. 1997 Apr 24;336(17):1216-22.
PubMed PMID: 9110909.


47: Sano M, Mackell JA, Ponton M, Ferreira P, Wilson J, Pawluczyk S, Pfeiffer E, 
Thomas RG, Jin S, Schafer K, Schittini M, Grundman M, Ferris SH, Thal LJ. The
Spanish Instrument Protocol: design and implementation of a study to evaluate
treatment efficacy Instruments for Spanish-speaking patients with Alzheimer's
disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord.
1997;11 Suppl 2:S57-64. PubMed PMID: 9236954.


48: Koss E, Weiner M, Ernesto C, Cohen-Mansfield J, Ferris SH, Grundman M,
Schafer K, Sano M, Thal LJ, Thomas R, Whitehouse PJ. Assessing patterns of
agitation in Alzheimer's disease patients with the Cohen-Mansfield Agitation
Inventory. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord.
1997;11 Suppl 2:S45-50. PubMed PMID: 9236952.


49: Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M, Ferris S. An
inventory to assess activities of daily living for clinical trials in Alzheimer's
disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord.
1997;11 Suppl 2:S33-9. PubMed PMID: 9236950.


50: Schneider LS, Olin JT, Doody RS, Clark CM, Morris JC, Reisberg B, Schmitt FA,
Grundman M, Thomas RG, Ferris SH. Validity and reliability of the Alzheimer's
Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's
Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S22-32.
PubMed PMID: 9236949.


51: Mohs RC, Knopman D, Petersen RC, Ferris SH, Ernesto C, Grundman M, Sano M,
Bieliauskas L, Geldmacher D, Clark C, Thal LJ. Development of cognitive
instruments for use in clinical trials of antidementia drugs: additions to the
Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's
Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S13-21.
PubMed PMID: 9236948.


52: Ferris SH, Mackell JA, Mohs R, Schneider LS, Galasko D, Whitehouse PJ,
Schmitt FA, Sano M, Thomas RG, Ernesto C, Grundman M, Schafer K, Thal LJ. A
multicenter evaluation of new treatment efficacy instruments for Alzheimer's
disease clinical trials: overview and general results. The Alzheimer's Disease
Cooperative Study. Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S1-12. PubMed
PMID: 9236947.


53: Grundman M, Corey-Bloom J, Jernigan T, Archibald S, Thal LJ. Low body weight 
in Alzheimer's disease is associated with mesial temporal cortex atrophy.
Neurology. 1996 Jun;46(6):1585-91. PubMed PMID: 8649553.


54: Kieburtz KD, Price RW, Sidtis JJ, Hall C, Grundman M, McLaren C. Pilot Study 
of Didanosine in Patients with HIV Dementia. J NeuroAIDS. 1996;1(4):1-5. PubMed
PMID: 16873174.


55: Sano M, Ernesto C, Klauber MR, Schafer K, Woodbury P, Thomas R, Grundman M,
Growdon J, Thal LJ. Rationale and design of a multicenter study of selegiline and
alpha-tocopherol in the treatment of Alzheimer disease using novel clinical
outcomes. Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord. 1996
Fall;10(3):132-40. PubMed PMID: 8876776.


56: Olichney JM, Hansen LA, Hofstetter CR, Grundman M, Katzman R, Thal LJ.
Cerebral infarction in Alzheimer's disease is associated with severe amyloid
angiopathy and hypertension. Arch Neurol. 1995 Jul;52(7):702-8. PubMed PMID:
7619027.


57: Masdeu JC, Van Heertum RL, Kleiman A, Anselmi G, Kissane K, Horng J, Yudd A, 
Luck D, Grundman M. Early single-photon emission computed tomography in mild head
trauma. A controlled study. J Neuroimaging. 1994 Oct;4(4):177-81. PubMed PMID:
7949553.


58: Hriso E, Kuhn T, Masdeu JC, Grundman M. Extrapyramidal symptoms due to
dopamine-blocking agents in patients with AIDS encephalopathy. Am J Psychiatry.
1991 Nov;148(11):1558-61. PubMed PMID: 1681751.


59: Masdeu JC, Yudd A, Van Heertum RL, Grundman M, Hriso E, O'Connell RA, Luck D,
Camli U, King LN. Single-photon emission computed tomography in human
immunodeficiency virus encephalopathy: a preliminary report. J Nucl Med. 1991
Aug;32(8):1471-5. PubMed PMID: 1869964.


60: Thal LJ, Grundman M, Klauber MR. Dementia: characteristics of a referral
population and factors associated with progression. Neurology. 1988
Jul;38(7):1083-90. PubMed PMID: 3386827.


61: Thal LJ, Grundman M, Golden R. Alzheimer's disease: a correlational analysis 
of the Blessed Information-Memory-Concentration Test and the Mini-Mental State
Exam. Neurology. 1986 Feb;36(2):262-4. PubMed PMID: 3945395.